Description
Generic Name:
Diltra PeP Tablet contains Tenofovir Disoproxil Fumarate, Lamivudine, and Dolutegravir, which are antiretroviral medications used for post-exposure prophylaxis (PeP) and HIV treatment.
Composition:
Each Diltra PeP Tablet consists of:
- Tenofovir Disoproxil Fumarate (300mg) – A nucleotide reverse transcriptase inhibitor (NtRTI) that prevents HIV replication.
- Lamivudine (300mg) – A nucleoside reverse transcriptase inhibitor (NRTI) that blocks viral multiplication.
- Dolutegravir (50mg) – An integrase strand transfer inhibitor (INSTI) that stops the virus from integrating into human DNA.
Indication:
Diltra PeP Tablet is indicated for:
- Post-exposure prophylaxis (PeP) to prevent HIV infection after potential exposure.
- HIV-1 infection treatment in adults and adolescents.
Storage Instructions:
- Store at room temperature (15-30°C) in a dry place.
- Keep away from moisture and direct sunlight.
- Keep out of reach of children.
- Do not use beyond its expiry date.
Uses of the Medicine:
- Reduces the risk of HIV infection after exposure (PeP).
- Helps manage HIV infection and improves immune function.
- Reduces viral load and prevents HIV progression.
- Lowers the risk of HIV-related complications.
Benefits of the Medicine:
- Effectively prevents HIV infection if taken within 72 hours of exposure.
- Suppresses HIV replication when used as treatment.
- Strengthens the immune system by maintaining CD4 cell count.
- Reduces the risk of opportunistic infections.
Side Effects:
Common side effects include:
- Nausea and vomiting
- Diarrhea
- Headache
- Fatigue
- Dizziness
- Difficulty sleeping (insomnia)
Serious Side Effects Include:
- Lactic acidosis (muscle pain, breathing difficulties, severe weakness).
- Liver toxicity (yellowing of skin/eyes, dark urine, severe abdominal pain).
- Kidney damage (changes in urine output, swelling in legs).
- Severe mood changes (depression, suicidal thoughts, anxiety).
- Bone loss (osteoporosis) (increased risk of fractures).
How to Use the Medicine:
- Take one tablet once daily, or as prescribed by your doctor.
- If using for PeP, start within 72 hours of exposure and continue for 28 days.
- Can be taken with or without food.
- Swallow the tablet whole with water. Do not crush or chew.
- Always take it in combination with other antiretroviral drugs if treating HIV.
How the Medicine Works:
Diltra PeP Tablet contains Tenofovir, Lamivudine, and Dolutegravir, which belong to NtRTI, NRTI, and INSTI classes. These drugs block reverse transcriptase and integrase, enzymes needed by HIV to replicate and integrate into human DNA. This prevents the virus from multiplying and reduces the viral load.
What If You Forget to Take the Medicine?
- Take the missed dose as soon as you remember.
- If it is close to the next scheduled dose, skip the missed dose and continue as usual.
- Do not take a double dose to make up for a missed one.
Quick Tips:
- If using for PeP, start immediately after exposure for the best protection.
- Take the medicine at the same time daily for maximum effectiveness.
- Regular blood tests are required to monitor health conditions.
- Avoid alcohol, as it may worsen liver-related side effects.
- Do not stop taking the medication without consulting your doctor.
- Maintain proper hygiene to prevent the spread of HIV.
Safety Advice

Alcohol
Caution is advised when consuming alcohol with Diltra Tablet. Please consult your doctor for guidance.
Pregnancy
Diltra Tablet is unsafe to use during pregnancy due to potential harm to the developing baby. It may only be prescribed in life-threatening situations where benefits outweigh the risks. Please consult your doctor.

Breastfeeding
There is insufficient information on the use of Diltra Tablet while breastfeeding. Please consult your doctor before use.

Driving
It is uncertain whether Diltra Tablet affects your ability to drive. Avoid driving if you experience drowsiness, dizziness, or reduced alertness.

Kidney
Limited data is available on the safety of Diltra Tablet in patients with kidney disease. Dose adjustments may be necessary. Please consult your doctor.

Liver
Diltra Tablet should be used with caution in patients with liver disease. Dose adjustments may be required based on the severity of the condition. Please consult your doctor.
FAQs:
Q: Can Diltra PeP cure HIV?
A: No, it helps control HIV but does not cure the infection. Lifelong treatment is required.
Q: How effective is Diltra PeP for preventing HIV?
A: It is highly effective if taken within 72 hours of exposure and continued for 28 days.
Q: Can I take this medicine during pregnancy?
A: It is sometimes prescribed during pregnancy, but consult your doctor before use.
Q: Does Diltra PeP affect kidney function?
A: Yes, it may cause kidney damage, so regular kidney function tests are recommended.
Q: Can I drink alcohol while taking this medicine?
A: It is best to avoid alcohol, as it may increase liver-related side effects.
Related Lab Tests:
- HIV Viral Load Test
- CD4 Cell Count Test
- Liver Function Test (LFT)
- Kidney Function Test (KFT)
- Bone Density Test
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