Description
Generic Name:
Twinaqt contains Dolutegravir and Rilpivirine as its active ingredients.
Composition:
Each tablet of Twinaqt contains:
- Dolutegravir (50 mg)
- Rilpivirine (25 mg)
Indication:
Twinaqt is indicated for:
- HIV-1 Infection: Used as a complete regimen for the treatment of HIV-1 infection in adults who are virologically suppressed on a stable antiretroviral regimen for at least six months.
- Helps maintain HIV suppression in patients who do not have a history of treatment failure.
Storage Instructions:
- Store at room temperature (15-30°C).
- Keep in a dry place, away from moisture and direct sunlight.
- Keep out of reach of children.
Uses of the Medicine:
- Used as a maintenance therapy for HIV-1 in patients who have achieved viral suppression.
- Helps in long-term management of HIV infection.
Benefits of the Medicine:
- Simplified two-drug regimen for HIV maintenance therapy.
- Helps maintain low viral load and high CD4 count.
- Reduces pill burden compared to three-drug regimens.
- Lower risk of drug interactions compared to protease inhibitors.
Side Effects:
Common side effects include:
- Headache
- Nausea
- Dizziness
- Fatigue
- Trouble sleeping (insomnia)
Serious Side Effects Include:
- Liver toxicity (hepatitis, jaundice)
- Severe skin reactions (Stevens-Johnson syndrome)
- Depression or mood changes
- Immune reconstitution syndrome
- Hypersensitivity reactions
How to Use the Medicine:
- Take one tablet once daily, preferably with food to enhance absorption.
- Swallow the tablet whole with water.
- Follow the doctor’s prescribed dosage strictly.
How the Medicine Works:
Twinaqt contains a combination of integrase strand transfer inhibitor (INSTI) and a non-nucleoside reverse transcriptase inhibitor (NNRTI):
- Dolutegravir: Blocks the integrase enzyme, preventing the virus from inserting its genetic material into human DNA.
- Rilpivirine: Inhibits reverse transcriptase, preventing HIV from replicating.
What If You Forget to Take the Medicine?
- Take the missed dose as soon as you remember.
- If it’s close to the next dose, skip the missed dose.
- Do not take a double dose to make up for the missed one.
Quick Tips:
- Take Twinaqt with food to improve drug absorption.
- Avoid antacids within 6 hours before or 4 hours after taking Twinaqt.
- Stay hydrated and maintain a healthy diet to support immune function.
- Do not stop taking the medicine without consulting your doctor.
- Inform your doctor if you experience mood changes or depression.
Safety Advice
Alcohol
Caution is advised when consuming alcohol with Twinaqt Tablet. Please consult your doctor for guidance.
Pregnancy
Twinaqt Tablet is unsafe to use during pregnancy due to potential harm to the developing baby. It may only be prescribed in life-threatening situations where benefits outweigh the risks. Please consult your doctor.
Breastfeeding
There is insufficient information on the use of Twinaqt Tablet while breastfeeding. Please consult your doctor before use.
Driving
It is uncertain whether Twinaqt Tablet affects your ability to drive. Avoid driving if you experience drowsiness, dizziness, or reduced alertness.
Kidney
Limited data is available on the safety of Twinaqt Tablet in patients with kidney disease. Dose adjustments may be necessary. Please consult your doctor.
Liver
Twinaqt Tablet should be used with caution in patients with liver disease. Dose adjustments may be required based on the severity of the condition. Please consult your doctor.
FAQs:
Q: Can Twinaqt cure HIV?
A: No, but it effectively controls HIV infection.
Q: Can I drink alcohol while taking Twinaqt?
A: Alcohol should be limited due to the risk of liver damage and increased side effects.
Q: Is Twinaqt safe during pregnancy?
A: Consult your doctor before use; Dolutegravir may require additional monitoring during pregnancy.
Q: How long does it take for Twinaqt to work?
A: It helps maintain viral suppression as long as taken regularly.
Related Lab Tests:
- HIV-1 RNA Test
- Liver Function Test (LFTs)
- Kidney Function Test (Creatinine, eGFR)
- CD4 Cell Count
- Electrolyte Monitoring
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