Description
Generic Name:
Dolutegravir + Emtricitabine + Tenofovir Alafenamide
Composition:
Each Alafevir DE Tablet contains:
- Dolutegravir (50mg): An integrase inhibitor that prevents the HIV virus from integrating into human DNA.
- Emtricitabine (200mg): A nucleoside reverse transcriptase inhibitor (NRTI) that blocks viral replication.
- Tenofovir Alafenamide (25mg): An NRTI that inhibits the virus’s ability to replicate and lowers viral load.
Indication:
Alafevir DE Tablet is indicated for:
- HIV-1 Infection Treatment: Used in combination antiretroviral therapy (ART) for adults and adolescents.
- Prevention of HIV Transmission: Helps reduce the risk of HIV spreading when taken consistently.
- Post-Exposure Prophylaxis (PeP): May be prescribed after potential HIV exposure to prevent infection.
Storage Instructions:
- Store at room temperature (15-30°C) in a dry place.
- Keep away from direct sunlight, moisture, and heat.
- Store in its original container with the lid tightly closed.
- Keep out of reach of children and pets.
Uses of the Medicine:
- HIV Treatment: Helps suppress viral load and prevents the progression of HIV.
- Prevention of HIV Transmission: Reduces the risk of transmitting HIV to others.
- Post-Exposure Prophylaxis (PeP): Can be used within 72 hours of HIV exposure to reduce infection risk.
- Combination Therapy: Used with other antiretroviral drugs for comprehensive HIV management.
Benefits of the Medicine:
- Potent Viral Load Suppression: Effectively reduces HIV levels in the blood.
- Improves Immune System Health: Increases CD4 cell count and helps prevent opportunistic infections.
- Once-Daily Dose: Enhances treatment adherence with a convenient dosing schedule.
- Lower Toxicity Risk: Tenofovir Alafenamide reduces kidney and bone-related side effects.
Side Effects:
Common side effects may include:
- Nausea, vomiting, or diarrhea
- Headache or dizziness
- Fatigue or weakness
- Insomnia or unusual dreams
- Mild skin rash
Serious Side Effects Include:
Seek immediate medical attention if you experience:
- Severe allergic reactions (swelling of the face, lips, or throat, difficulty breathing).
- Liver toxicity (yellowing of skin/eyes, dark urine, persistent nausea).
- Lactic acidosis (muscle pain, trouble breathing, drowsiness).
- Kidney problems (reduced urination, swelling, back pain).
- Mood changes, including depression or suicidal thoughts.
How to Use the Medicine:
- Take Alafevir DE Tablet once daily, exactly as prescribed.
- Swallow the tablet whole with water; do not crush or chew.
- Can be taken with or without food.
- If using for PeP, complete the full 28-day course for effectiveness.
- Consistent adherence is crucial for successful treatment.
How the Medicine Works:
Alafevir DE Tablet combines three powerful antiretroviral drugs that work by blocking different steps of the HIV replication cycle. Dolutegravir inhibits viral integration into human DNA, while Emtricitabine and Tenofovir Alafenamide prevent the virus from multiplying, leading to reduced viral load and improved immune function.
What If You Forget to Take the Medicine?
- Take the missed dose as soon as you remember.
- If it is close to the next scheduled dose, skip the missed dose.
- Do not take a double dose to compensate for a missed one.
Quick Tips:
- Take Alafevir DE Tablet at the same time each day to maintain drug levels.
- Avoid alcohol and recreational drugs to reduce side effects.
- Use protective measures like condoms to minimize the risk of HIV transmission.
- Get regular blood tests to monitor kidney and liver function.
- Inform your doctor about other medications to avoid interactions.
Safety Advice
Alcohol
Caution is advised when consuming alcohol with Alafevir DE Tablet. Please consult your doctor for guidance.
Pregnancy
Alafevir DE Tablet is unsafe to use during pregnancy due to potential harm to the developing baby. It may only be prescribed in life-threatening situations where benefits outweigh the risks. Please consult your doctor.
Breastfeeding
There is insufficient information on the use of Alafevir DE Tablet while breastfeeding. Please consult your doctor before use.
Driving
It is uncertain whether Alafevir DE Tablet affects your ability to drive. Avoid driving if you experience drowsiness, dizziness, or reduced alertness.
Kidney
Limited data is available on the safety of Alafevir DE Tablet in patients with kidney disease. Dose adjustments may be necessary. Please consult your doctor.
Liver
Alafevir DE Tablet should be used with caution in patients with liver disease. Dose adjustments may be required based on the severity of the condition. Please consult your doctor.
FAQs:
Q: Can Alafevir DE Tablet cure HIV?
A: No, it helps manage HIV but does not cure it. Lifelong treatment is required.
Q: Can pregnant women take Alafevir DE Tablet?
A: It should be used with caution in pregnancy. Consult your doctor before taking it.
Q: How long does it take for Alafevir DE Tablet to show results?
A: Viral load reduction can be seen within a few weeks of regular use.
Q: Can I take Alafevir DE Tablet with food?
A: Yes, it can be taken with or without food.
Related Lab Tests:
- HIV Viral Load Test (to monitor treatment progress).
- CD4 Cell Count (to assess immune function).
- Liver and Kidney Function Tests (to check for drug toxicity).
- Complete Blood Count (CBC) (to monitor overall health).
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